The genus Musa contains approximately 70 species, with more than 300–500 different varieties (Häkkinen, 2009 Maduwanthi & Marapana, 2019). Our investigation provides a rationale for the use of banana flesh to minimize the risk of cancer-like diseases.įruits are a rich source of vitamins and sugars, along with diverse phytochemical contents, and have been linked to reducing the risk of major chronic degenerative diseases including cancer.īanana, one of the widely consumed fruits worldwide, belongs to the genus Musa in the family Musaceae (Singh et al., 2016). Gas chromatography mass spectrometry (GC-MS) analysis of HE identified several anticancer compounds including palmitic acid, linoleic acid, oleic acid, campesterol, stigmasterol, and γ-sitosterol, supporting the anticancer potential of HE. HE induced apoptosis in PANC-1 and MDA-MB-231 cells, as evidenced by the appearance of condensation of chromatin, proteolytic activation of caspase-3 and 7, and increase in the level of the cleaved form of poly (ADP-ribose) polymerase protein. According to the IC 50 values in various cancer cell lines, HE was found to possess the greatest cell growth inhibitory potential in human pancreatic cancer PANC-1 cells and human triple-negative breast cancer MDA-MB-231 cells.

) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid) (ABTS.HE was found to exert a strong radical scavenging activity on 2,2-diphenyl-1-picrylhydrazyl (DPPH

Of the four kinds of banana flesh extracts, the hexane extract (HE) had the highest total polyphenol content (2.54 ± 0.60 mg GAE/g) and total flavonoid content (1.69 ± 0.34 mg RE/g), followed by the chloroform fraction, total ethanol extract, and ethanol fraction. In this study, the antioxidant and the anticancer potential of banana flesh was investigated. Bananas, one of the most widely consumed fruits worldwide, are a rich source of valuable phytochemicals.

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